Palmitoylethanolamide (PEA) is an endogenous fatty acid amide, belonging to the class of nuclear factor agonists. PEA has been demonstrated to bind to a receptor in the cell-nucleus (a nuclear receptor) and exerts a great variety of biological functions related to chronic pain and inflammation. The main target is thought to be the peroxisome
proliferator-activated receptor alpha (PPAR-alpha).Palmitoylethanolamide powder
PEA has been shown to have anti-inflammatory, anti-nociceptive, neuroprotective, and anticonvulsant properties.
Palmitoylethanolamide (PEA), is a fatty acid amide, and is a naturally occurring substance within our bodies. Fatty acid amides are, as the name suggests, an amide formed from a fatty acid and an amine. Amines are a functional group that consist of a nitrogen atom in combination with three carbon atoms and/or hydrogen atoms. Fatty acid amides are vital to the chemical signaling processes within our bodies.
PEA is produced within our cells, and within the body it contributes to the homeostasis, or balance, of the body.
1. Pain reliever
(1) palmitoylethanolamide is a good painkiller, specifically for chronic pain. Additional to pain relief it recently became clear that palmitoylethanolamide can relief anxiety and
depression and showed an anti-epileptic effect in animal studies. Recently palmitoylethanolamide turned out to increase the immune cells capacity to destroy bacteria.
(2) Palmitoylethanolamide (PEA) binds to nuclear receptors in cells and produces a variety of effects that help deal with chronic pain and inflammation. This is our bodies’ way of
battling these issues and it works rather well, since palmitoylethanolamide is a natural substance with no side-effects whatsoever. The problems occur when the pain is chronic,
since our bodies can’t produce enough PEA. The help comes in the form of capsules containing PEA as a supplement. This is the perfect way to increase the amount of
palmitoylethanolamide in your organism to help you deal with almost any kind of pain.
2. Fever reducer
(1) Using palmitoylethanolamide (PEA) is a way to deal with fevers that is as natural as the cause of fever itself. PEA has been known to relieve pain and have great anti-
inflammatory effects, but it has been proven to stabilize the mast cells as well. These cells play an important role when it comes to hay fever and managing their operation can
have extremely positive effects on reducing inflammation.
(2) Higher concentrations of pollen in the air make the mast cells overly active and they produce substances that cause the symptoms of hay fever.
3. Anti-inflammatory
(1) Palmitoylethanolamide can be found in our bodies as it is a natural compound that is used to reduce inflammation and pain. Ever since 1980s scientists have known about
amazing anti-inflammatory effects of PEA. In about two decades before that there had been numerous studies that separated PEA from other anti-inflammatory treatment methods
due to its fantastic effects and utter lack of side effects which makes it perfectly suitable for children as well.
(2) One of the studies from 1975 published in The Lancet compared the effects of 3 g of aspirin a day to 1.8 g of PEA a day. The effects of both were noticeable improvements in join movement and reducing pain.