PayDotCom caters more to the internet marketing crowd. This can be a little limiting, especially if your niche is knitting or golf...but they are adding new products every day, so I would say for sure you would want to check them out. Another thing to note is that they carry physical products as well as digital. Some niches just seem to do better with physical products, so if this is true for your niche, you may find just the thing you are looking for at PayDotCom.
If you can't find it there, you probably will at either Commission Junction or LinkShare. They both deal in physical products and allow you to market for some of the bigger names in business...like Best Buy and Office Depot.
https://www.shareasale.com/r.cfm?b=40&u=2589339&m=47